Custom Peptide Synthesis Blog

From the enhance of skin collagen to the production of cutting edge pharmaceutical products; every single chemical, as well as a biological phenomenon in the human life and its surrounding ecosystem, involves the usage of interconnected linkages of amino acids or proteins. The large network of interconnected mono components is called peptides, whereas the customized formation of peptide products is known as Custom Peptide Synthesis .  Now the long span of the peptide chain, as well as longevity of its chemical viability, play a major role in the conjunction of peptides and how they can be implemented for a wide diversity of products starting from combining API peptides to high production library peptides along with the creation of array peptides as well. Which is why, keeping in mind the budding significance of peptide compounds, a large number of pharmaceutical production companies have funded their assets and brains into a better fabrication of peptide products. Safegua...

In terms of organic chemistry, peptide synthesis can be referred as a production of peptides, compounds which are formed with the linking of amino acids through amino bonds, usually called as peptide bonds. A chain of usually 30-35 amino acids is formed in one bond. The condensation reaction of the carboxyl group of one amino acid to the amino group of another synthesizes the peptides. The use of this method is common in areas like biological research and product and drug development. Significant commercial and pharmaceutical products are a form of peptide synthesis such as: ·          Dipeptide sugar substitute ·          Clinically used hormones like oxytocin and adrenocorticotropic. ·          400+ peptides are used in clinical studies SPPS – Solid Phase Peptide Synthesis The synthesis of peptide was first recorded in the early 50’s or 60’s, b...

Peptide Synthesis From the last 40 years or so Merrifield solid peptide synthesis has been a standard research procedure used in the further study of chemistry and biological usage of deamidation of asparaginyl and glutaminyl residues in peptides. In its primary investigation, initially, it permitted the qualitative demonstration in three different structure-determining deamidations which varied over a wide range in different biological conditions and the discovery of two biological systems took  place in which deamidations works as molecular clocks. In the recent times, a thorough quantitative understanding of the structural dependence of deamidation became possible which results in deamidation rate of asparaginyl residues in protein can be predicted from three-dimensional structure of protein with a high degree of accuracy. In his investigation, Professor R.B. Merrifield discovered that amide residues serve as molecular clock in many biological systems. It is this technique on w...

Peptide  is becoming more in demand since natural protein is limited for research and clinical purposes. Moreover, for diagnostic and drug discoveries the length of peptide is a concern among the scientists. To meet specific demands a lot of  peptide synthesis service providers  are offering  custom peptide synthesis  for you. Bio-synthesis, one of the leading service providers of peptide synthesis is offering  Custom Peptides Synthesis  which is performed in order to produce research-grade or bulk API polypeptides. These peptides can also be modified during synthesis for specific diagnostic and therapeutic applications. Liquid Phase Custom Peptide Synthesis (LPPS) is used for very short dipeptide synthesis, while large-scale Solid Phase Custom Peptide Synthesis (SPPS) is suited for preparing biologically active peptides including long, difficult and hydrophobic peptides. The best thing custom peptide synthesis from  Bio-Synthesis  is that i...

Peptide  array is an important component in a wide product from  Bio-synthesis  which is uniquely integrated to suit the proteomics services of the company. Bio-Synthesis offers custom peptide array synthesis and peptide array synthesis services to assist and help out client in their discovery tryst of new drugs and clinical innovations. Peptide array is one of the most powerful tools in the hands of researchers for the investigation of protein-to-protein and drug-to- protein interactions. In drug development screening of peptides for the most probable active compound with peptide array is a lot of convenient methods used in basic and applied research across the globe. Here are some basic applications and principals of peptide microarrays.  A range of varied peptide array based services is available with Bio-synthesis, like epitope mapping, substitution analysis, and others. Before going further we shall try to understand that for peptide-based drug design it is pos...

The world is progressing and it is progressing rapid and fast. To speed up the process of  peptide synthesis  MIT researchers have designed a new machine that can rapidly produce large quantities of custom peptides. Producing small proteins known as peptides is usually a very time-consuming process, which has sluggish the development of new peptide drugs for diseases like cancer, diabetes, and bacterial infection. The new tabletop machine designed by MIT researchers can form links between amino acids (building block of proteins) in about just 37 seconds, and it takes less than an hour to produce complete peptide molecules containing nearly 60 amino acids. “You can dial in whatever amino acids you want, and the machine starts printing off these peptides faster than any machine in the world,” says Bradley Pentelute, the Pfizer-Laubach Career Development Associate Professor of Chemistry at MIT. This technology, therefore, could help researchers quickly generate ne...

Peptide purification is indeed necessary to get quality peptides for research. Most of the  peptide synthesis services  purify the products using reverse-phase high-performance liquid chromatography (HPCL). However, sometimes some other methods like ion exchange or gel filtration chromatography too are used. Custom peptides that are difficult to produce will require special services. When placing an order for synthesized peptides it is obvious that customers request the highest purity that  peptide synthesis service  offers. It is always better to use reagents that are free from impurities. However, sometimes using the less pure sample is effective in cost terms for those experiments which don’t require ultra-pure peptides. Peptide synthesis service providers almost invariably offer more than three levels of purity labeled as X%. What are the differences and what purities are best in various experiments? Lower levels of purity Generally, the level of purit...